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However, it showed good selectivity over PDE1, with a selectivity factor of 164 [245], as well as good efficacy when tested in an ex vivo vasodilatation model with an EC 50 of 1.63 M [246]

These findings suggest that MSG may increase cellular oxidative stress by suppressing the antioxidant defense system, and TA may significantly alleviate these adverse effects both at the gene level and in terms of enzyme activity, thus renormalizing the cellular redox level

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Videnovic A, Amara AW, Comella C, Schweitzer PK, Emsellem H, Liu K, et al

Cells were treated with 40100 M KL1 or 110 M BIX-01294 in the presence of 50 g ml 1 Gen in 5 replicates for 48 h