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An autoimmune stem-like CD8 T cell population drives type 1 diabetes

10.1111/j.1600-0625.2007.00613.x 228

This local hepatic inflammation leads to further recruitment of systemic inflammatory cells, such as neutrophils, T-cells and monocytes, which perpetuate additional inflammation, hepatic fibrosis, hepatocyte cell death (68, 72, 73) that ultimately leads to rapid progression to multiple organ failure (74)

This AOP identifies the deposition of ionizing energy as the MIE, leading to DSB and subsequent mutations due to the errors in DNA repair mechanisms

"We continue to support our players during this process and we have brought in independent medical and pharmacological advice which has provided comfort to the Club about the safety of our players