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Immune cells and metabolites produced by gut bacteria can move through the circulatory system to stimulate immune responses in the lungs, while the lung microbiota can induce microbial changes in the blood and gut ( 2 Microbiota and COPD 2.1 Lung microbiota and COPD Traditionally, lungs are considered sterile spaces, but in fact, they have their own microbial community composed of bacteria, viruses, and fungi ( Proteobacteria, Firmicutes, and Bacteroidetes are the most common genera in COPD patients, while at the genus level, Pseudomonas, Streptococcus, Prevotella, Fusobacteria, and Veillonella are the main genera

DNA methylation was measured using global DNA methylation (5-mC) ELISA

953 Nevertheless, AGLs poor water solubility limits its practical application

Rates of deficiency tend to be higher among people with impaired kidney function

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