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(III.2.F) EXVIVO STUDY Ex vivo study on goat sublingual mucosa shows increase in permeation of drug through mucosa than that of In vitro condition because chitosan is able to break tight junction hence facilitate the passage of drug through this route .On the other hand PG will increase the pore size of the membrane along with alcohol as a result increase in Para-cellular movement of the drug .Therefore Ex- vivo data will help to predict In- vivo permeation pattern of the formulation

So while BPC 157 is not a sedative and doesnt directly induce sleep, it can create the physiological conditions for restorative restby reducing obstacles to sleep, supporting neurotransmitter balance, and enhancing the bodys natural recovery processes that occur during sleep cycles

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