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Embryonic lethality demonstrated before Day 7.5 of gestation in complete knockout mice was potentially attributable to secondary mitochondrial dysfunction from the effect on flavocoenzyme deficiencies on the electron transport chain, which is critically involved in energy generation [47]

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El Kodsi DN, Tokarew JM, Sengupta R, Lengacher NA, Ng AC, Boston H, Jiang Q, Palmberg C, Pileggi C, Shutinoski B, Li J, Nguyen AP, Fehr TK, Im DS, Callaghan S, Park DS, LaVoie MJ, Chan JA, Takanashi M, Hattori N, Ratan RR, Zecca L, Puente L, Shaw GS, Harper M-E, Holmgren A, Tomlinson JJ, Schlossmacher MG (2020) Parkinson disease-linked Parkin mediates redox reactions that lower oxidative stress in mammalian brain