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Understanding the complex absorption process of vitamin B12 helps explain why some individuals develop deficiency despite adequate dietary intake, and why different supplementation strategies may be necessary for different people

Notably, researchers have documented that the peptide appears to upregulate NO production when it is deficient and downregulate it when excessive, suggesting a modulatory rather than simply stimulatory relationship

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Scientists use it as a biochemical probe to better understand NNMT's contributions to lipid metabolism, mitochondrial function, and metabolic signaling networks

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