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Next, we used sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) to analyze the protein corona in serum from mice given the various liposome formulations and found that the concentration of PEG-ITP-Lip/ITP-Lip was significantly lower than that of IEP-Lip in terms of both the adsorbed protein species and the protein amount (Fig

It: Binds approximately 7590% of circulating IGF-1 Regulates how much IGF-1 is bioavailable (free to act on tissues) Is produced primarily by the liver, in response to growth hormone signaling - with IGF-1 serving as a key mediator of GHs effects on tissue growth and development Think of IGFBP-3 as a traffic controller: it determines how much of IGF-1s potent growth signal reaches your cells