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Oncogene 26 , 53105318

Knockout of MORs from NAc medium spiny neurons (MSN) reduces the ability of MORs to inhibit GABA input to local VTA GABA interneurons in VTA (Charbogne et al., 2017)

MORs and DORs inhibit ON cell responses, increase activity of OFF cells, and have no effect on NEUTRAL cells (Cheng et al., 1986

It shows an association of mutated NRAS with increased HGF-dependent activation of c-Met and with enhanced sensitivity to c-Met inhibition [81]

Su desarrollo clnico avanz desde ensayos de fase 2 en monoterapia para obesidad y sobrepeso hacia su combinacin con semaglutida ( CagriSema ), que lleg a fase 3 dentro del programa REDEFINE, incluido el estudio REDEFINE-1 de 68 semanas