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A diagnosis of primary carnitine deficiency requires that serum, red cell and/or tissue carnitine levels be low and that the patient does not have a primary defect in fatty acid or organic acid oxidation (see CLINICAL PHARMACOLOGY )

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Apart from these origins, other important sources of endogenous oxidants involve nitric oxide synthase, cytochrome p450, monoamine oxidase, various oxidoreductases such as mitochondrial respiratory chain (RC), xanthine oxidase, and enzymes responsible for infection and inflammatory responses to stimulate xenobiotic for instance NADPH oxidases [25]

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Cai Y, Shen X, Ding C, Qi C, Li K, Li X, et al

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