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Apart from this redox axis Keap1 also works independently of Nrf2 to modify the mitogen-activated protein kinase (MAPK) pathway

The heterogeneity between patients indicates the complexity of the pathogenesis of SS and often results in delays in disease diagnosis (231)

doi: 10.1158/1940-6207.CAPR-15-0236 165 LabunskyyVMHatfieldDLGladyshevVN

Calcium dense deposits have been demonstrated inside the enlarged mitochondria in renal tubular cells of the stone formers by electron microscopy without crystalline structure observed (Harrison et al., 1988)