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The amine group of lysine can become mono-, di-, or trimethylated by histone methyltransferases (HMTs) [20], and demethylated by histone demethylases (KDM) [21, 22], altering chromatin structure and thus regulating transcription [22]

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In contrast to the ABC transporters, SLC transporters can facilitate the bidirectional movement of substrates based on their existing concentrations across the cell membrane