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L., Fu, A., Zhao, P., Li, J., Geng, L., Smith, S

Nature 615 , 668677 (2023)

Within MTH1s active site, 8-oxo-dGMP adopts an antipodal conformation, engaging in -stacking interactions with Trp117 and Phe72

Babies need folate for the spinal column to develop fully, and the MTHFR variants increase the risk of problems.[ref] This is why prenatal vitamins contain folate and why folic acid is added to white rice and white flour