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10.1016/j.lfs.2009.02.026 Life Sci

With rapid weight reduction by GLP-1 agonists, muscle NAD+ also drops

2 way Dual Activation GHRH-R (CJC-1295) + GHS-R1a (Ipamorelin) two complementary pituitary targets 2-4x GH AUC Demonstrated Synergy Area under the GH curve 2 to 4 times greater than each peptide in monotherapy 5.8 - 8.1 days CJC-1295 Half-Life Sustained elevation of IGF-1 for 9 to 11 days after a single injection 10 mg Pre-formulated mix 5 mg CJC-1295 (No DAC) + 5 mg Ipamorelin per vial | Purity 99% HPLC Selective Hormonal Profile Ipamorelin: no increase in cortisol, prolactin or ACTH (Raun et al., 1998) Mechanism of Action Dual-Channel Synergy Simultaneous activation of GHRH-R and GHS-R1a for amplified GH stimulation GHRH Lane CJC-1295 GHRH Analog (Mod GRF 1-29) A synthetic peptide of 29 amino acids that selectively binds to the GHRH receptor on pituitary somatotroph cells

The ultimate goal is to inspire future research to overcome existing research limitations and develop novel preventive and therapeutic approaches, thereby offering actionable solutions to mitigate aging-related diseases and extend the healthspan of the elderly population

(2019) Transketolase and vitamin B1 influence on ROS-dependent neutrophil extracellular traps (NETs) formation