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A randomized clinical trial on patients with DM and CAD found that melatonin improved glycemic control, high-density lipoprotein-cholesterol, blood pressure, C-reactive protein, nitric oxide, malondialdehyde, glutathione and even mental health parameters (measured via Beck Depression Inventory) [90]

Hormonal imbalances can also cause several mental health issues such as mood swings and depression

Isothermal self-assembly of multicomponent and evolutive DNA nanostructures

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Hence, plasma exosomal CYP2E1 load, along with other relevant CYPs, can be taken into consideration while studying DDI and pharmacokinetic profiling of new and existing drugs