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3 Clinical Outcomes in ALS The US Food and Drug Administration (FDA) provides guidance on important outcomes in ALS clinical trials, such as mortality, functional status, respiratory and strength measures, and patient-reported outcomes [27]

In contrast, the internal mucus layer is nearly sterile due to the presence of antimicrobial peptides and size-limiting meshes, which prevent bacterial penetration into the inner mucus layer [20]

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It is important to keep in mind that many of the biological activities discussed below were observed in cells cultured in the presence of resveratrol at higher concentrations than those likely to be achieved in humans consuming resveratrol orally (see Metabolism and Bioavailability)