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Individuals with reduced activity of the DHFR enzyme, which is responsible for the first step in folic acid metabolism, may be less able to convert folic acid efficiently

Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults

J.BarbasC.DaiberA.et al

Since inhibition of Topoisomerase I might lead to DNA damage, we assessed the levels of p53 phosphorylation on Ser15 [a residue that can be phosphorylated by ATM/ATR 25 ] and found that indeed parental and resistant cells treated with T-DXd display this post-translational modification (Fig