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Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

Lythgoe, A

The present review initially presents several actions of melatonin in health and disease, followed by the key pathophysiological mechanisms of COVID-19 and the potential mechanisms through which melatonin would interact and mitigate them, with a focus on long COVID and the mitochondrial functions of melatonin

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In addition, Mn exposure activates canonical inflammatory pathways particularly the NF-B and ERK1/2 pathways thereby inducing proinflammatory transcriptional programs in neural and nonneural cells and contributing to the pathogenesis of central nervous system (CNS) injury 175,176