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Bibcode:2019JAChS.14114210L

This free cytoplasmic B12 undergoes a series of intracellular transport and modifications to enable two core enzymatic reactions: 1) adenosyl-B12 acts as a co-factor for the enzyme methylmalonyl-coA mutase that catalyzes the conversion of methylmalonyl-coA to succinyl-coA, thereby enabling restoration of tricarboxylic acid (TCA) cycle intermediates and 2) methyl-B12 enables methionine synthase in the re-methylation of homocysteine to methionine using methyl-tetrahydrofolate (MTHF) as a methyl donor, thereby enabling the vital biochemical pathways of the folate cycle and methionine cycle, facilitating the downstream synthesis of important compounds like DNA and RNA (Figure 2)

Researchers are still studying the ideal duration and frequency for long-term safety

Alternatively, ZSS powder or extracts can be mixed with excipients and pressed into tablets, similar to standard tablets, making them easy to carry and prescribe

doi: 10.1007/s12016-007-8007-4 150 KapsogeorgouEKTzioufasAG