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Quality assessment of the included studies The Systematic Review Centre for Laboratory Animal Experiments (SYRCLE) tool was used to determine the "risk of bias" in the included studies (Figure 2) []

[DOI] [PubMed] [Google Scholar] 86.Michishita, E., Park, J

Supplementary Materials The following supporting information can be downloaded at: Table S1: PRISMA checklist

Its an autoimmune disease in which the immune system produces antibodies that attack the thyroid, causing fibrosis or scarring of the thyroid tissue ( Hashimotos disease is associated with a variety of symptoms, including weight gain, fatigue, hair loss, anemia, constipation, cold intolerance, joint pain, dry skin, mood changes, difficulty concentrating, and more ( In addition to medication, diet and lifestyle modification can help reduce thyroid damage and improve symptoms and overall quality of life in people with Hashimotos

Apropos the above, the most common type of pain in PD is musculoskeletal, related to local nociception rather than a centrally-mediated mechanism, which may respond to anti-inflammatory medications such as NSAIDs