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One major challenge in treating melanoma is drug resistance [259]

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Although there are many similarities between dogs and humans, there also are many important differences.30, 31, 32, 33 Dogs present an interesting challenge in the assessment of P450-mediated drugdrug interactions because most of the enzymes have not been completely characterized, diet and aging induce significant changes in gene expression, and dogs are often treated off-label with a number of human drugs with little idea of risk for drugdrug interaction