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The heritable genetic sequence of an individual will determine the specific activity and how many copies of enzymes controlling the level of GSH and GSSG are present in each cell, Figure 4

Additionally, mice with liver-specific -catenin deletion also have liver metabolic zonation disorders and cause the liver to exhibit a periportal phenotype overall (52)

Given the importance of this organelle, maintenance of proper mitochondrial function and structure is essential, and dysfunction is a pathological hallmark of metabolic, muscular, and neurodegenerative conditions, which can be associated with aging in multiple tissues 88,89