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Disruption of this axis, often due to gut microbiome dysbiosis, leads to intestinal dysfunction and systemic inflammation

High RDW with high MCV (large cells, varied sizes) suggests vitamin B12 or folate deficiency

They prevent the breakdown of NO-derived cGMP in vascular smooth muscle cells by competing with cGMP for the PDE5 catalytic site

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Understanding Vitamin B: What It Is and Its Role in the Body The body needs B vitamins for energy production, neurotransmitter synthesis, and red blood cell formation