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Tops initiated partly the cell recovery following the cell mortality by tert -butyl hydroperoxide, which showed other relevant mechanisms rather than PI3K/Akt and HO-1 were responsible for Tops initiated cell recovery[]

Front Pharmacol (2017) 8:296

Glutathione deficiency contributes to oxidative stress leading to aging and the pathogenesis of many diseases (including kwashiorkor, seizure, Alzheimer's disease, Parkinson's disease, liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, hea

TC2N has been demonstrated to activate the Wnt signalling pathway, thus promoting the invasive metastasis of HCC cells

Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer persister cells 2,3,4