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Evodiamine promotes LAST1 phosphorylation and inhibits YAP1 expression in HCC cells, resulting in YAP1 phosphorylation and reduced nuclear translocation, thus inactivating its downstream effector molecules (182)

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Results The conserved C-terminus determines S protein trafficking and coatomer interactions To determine whether residues in the SARS-CoV-2 S tail are under selection pressure, we analyzed over 11 million sequences of full-length SARS-CoV-2 S in the GISAID database 55,56 (Fig