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The FKBP5 gene encodes the FKBP51 protein, which regulates endocrine stress responses by modulating glucocorticoid signaling

Skin brightening works by inhibiting melanin production

However, acute overdoses and long-term treatment can cause hepatotoxicity

doi: 10.1016/j.ejphar.2018.04.019 153 YuW

Mechanistically, the inflammatory response after heart transplantation is mediated by TLR4/TRIF signaling pathway, which facilitates neutrophil migration to coronary endothelial cells, resulting in ferroptosis in the transplant endothelial cells