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Sun et al

Nutrients 13:2878

doi: 10.1053/j.jrn.2020.11.008 208 YangY.GongS.ZhouC.XinW.QinS.YaoM.et al

Oxidative stress affects numerous molecular pathways, including inhibition of the cystine/glutamate antiporter system, decreased expression of GPX4, disruption of iron homeostasis and lipid peroxidation, which is a major driver of ferroptosis activation (54)

However, increasing the amount of GSH available to the system was able to moderate this response, reducing the severity of E hc disruption to notionally acceptable levels