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As the fourth selenoprotein in the glutathione peroxidase family, GPX4 (originally termed PHGPX for its phospholipid hydroperoxide-reducing capacity) serves as the unique enzymatic regulator of lipid peroxidation through its distinctive structural and functional properties (Zhang W

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prodrugs contemplated in this invention include, but are not limited to, analogs or derivatives of compounds of any one of the formulae disclosed herein that comprise biohydrolyzable moieties such as biohydrolyzable amides, biohydrolyzable esters, biohydrolyzable carbamates, biohydrolyzable carbonates, biohydrolyzable ureides, and biohydrolyzable phosphate analogues

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Growth Hormone & IGF Research 19(6):424-431. [PubMed]

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