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It has been shown that upregulated MMPs in activated astrocytes in the ONH degrade the extracellular matrix (ECM) after retinal I/R injury in mice.[53] As a consequence the ECM is remodeled and degeneration of the lamina cribrosa occurs, which predisposes the RGCs towards compression[54, 55] and can cause further vascular dysregulation.[56] Indeed, we previously showed that the thickness of the lamina cribrosa, which indicates its degeneration, was related to BF in the ONH in glaucoma.[57] Astrocytes also release endothelin, which acts as a strong inducer of vasoconstriction[50] and prevents axonal transportation in the RGCs.[58] Furthermore, although NO in the astrocytes does not itself damage RGCs, it can be converted into the form of peroxynitrite (ONOO - )

doi: 10.2527/jas.2013-7164 [DOI] [PubMed] [Google Scholar] 34

While they probably wont have the same significant effect on stretch marks as some other treatments, they are a helpful preventative measure when used early on during periods of weight fluctuations like pregnancy in which stretch marks are just developing or expected to form

Fraquelli M, Pagliarulo M, Colucci A, Paggi S, Conte D