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A meta-analysis of 61 studies on 335 pediatric AI-ALF patients (67% females with a median age of 10 years) showed that 60% survived with their native liver, while 35% underwent LT and 5% died without LT

The opt3-3 mutant exhibits lower Cu in the phloem sap and impaired Cu recirculation from source to sink tissues (Chia et al., Reference Chia, Yan, Rahmati Ishka, Faulkner, Simons, Huang, Smieska, Woll, Tappero, Kiss, Jiao, Fei, Kochian, Walker, Pieros and Vatamaniuk2023)