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ZhouANiJXuZWangYLuSShaWet al

A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification

Cis-DDPs well-known nephrotoxicity, indeed, has been proved to be related to his GSH-conjugated compounds that, being metabolized to cysteine S-conjugate by cysteine S-conjugate -lyase activity (highly expressed in renal cells), is mainly responsible for proximal tubule cell damage [114]