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Subsequently, NLRP3 leads to the activation of caspase 1

Only the derivatives 35 and 37 , which bear a 2-aminoethyl-thionyl or a 2-chloroethyl-thionyl chain, respectively, showed a leishmanicidal response with a discrete IC 50 of 52.9 M and 27.9 M against promastigotes of L

Hagiwara, H

In colorectal tumor-bearing mice, the ketogenic formula suppressed systemic inflammation associated with tumors, such as lowering plasma IL-6 levels (150)

During sepsis, immune cells such as neutrophils and macrophages are rapidly activated in response to microbial invasion, releasing large amounts of ROS, including superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH ), as part of the hosts antimicrobial arsenal (Di Meo et al., 2016)