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To investigate this, we generated ATP7B-KO HepG2 cells in which PrP expression was permanently knocked down via stable shRNA transfection (Supplementary Fig

The MVA pathway starts with acetyl CoA, which undergoes a series of reductase reactions, including 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), leading to the production of MVA

Previous studies have mainly focused on the role of ferroptosis in neoplastic and some neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease, and Huntingtons disease ( Links Between Ferroptosis and Epilepsy Epilepsy is characterized by excessive, synchronous and aberrant firing of neurons originating from different cerebral cortices