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The reconstituted solution is then administered slowly

The immunogenicity of the RBD may be enhanced by presenting multiple copies of the RBD on a single particle to B cells, allowing multiple antigen-BCR engagements

This is exactly how experienced researchers handle the transition, and it is why many prefer to keep both a 10mg vial (reconstituted at 5mg/mL) and a 20mg or 30mg vial (reconstituted at 20mg/mL) available during the crossover period

Subsequently, N-Hydroxylamine (0.5 M) was added to the antibodies at volume ratio of 1:10 for 2 h to generate sulfhydryl groups