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Clin Chem Lab Med 54:11051109 Moreau P, Dimopoulos MA, Mikhael J, Yong K, Capra M, Facon T et al (2021) Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial

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[2] Estradiol cypionate injection is compounded on an individualized basis by 503A pharmacies pursuant to a patient-specific prescription and may also be produced in cGMP-compliant batches by 503B outsourcing facilities for office use, allowing clinicians flexible access to bioidentical estrogen preparations while maintaining regulatory oversight of quality and sterility

They have to bypass the gut entirely

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