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J Cell Biol 2008

The main practical disadvantages are: poor absorption in standard capsule form, the need for consistent daily use over 8-12+ weeks before visible results, relatively higher cost for well-absorbed formats, mild and uncommon side effects like digestive discomfort or headache in some users, and the risk of unrealistic expectations from aggressive marketing claims

Side effects occurred at higher rates with the participants taking Ozempic compared to placebo groups

Cani PD, Possemiers S, Van de Wiele T, et al

[DOI] [PubMed] [Google Scholar] Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, Padayatty S, Sun H, Wang Y, Nussbaum RL, Espey MG, Levine M