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It is known that by 1 week of cuprizone administration, microglia are activated in the corpus callosum 23 , with astrocytes showing morphological changes as early as 1 week and increasing in density by 3 weeks 24

doi: 10.3389/FBIOE.2020.00910 141 RaiM.WypijM.IngleA

However, the link between DSIP and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor

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Bottom row: NMR solution structure of the nucleocapsid protein from human immunodeficiency virus type 1 group M subtype B (isolate MN) (PDB ID: 1AAF) (Summers et al., 1992), NMR structure of Megabalanus rosa Cement Protein 20 (PDB ID: 6LEK) (Mohanram et al., 2019), NMR structure of the major house dust mite allergen Der p 2 (PDB ID: 1A9V) (Mueller et al., 1998), and X-ray crystal structure of E