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A., McPhee, A

Neither agent is currently approved for routine clinical use in the UK, and both remain under active investigation

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doi:10.1016/j.ijpharm.2021.121010 55

However, the vast heterogeneity of the pathogenic mechanisms underlying these conditions, along with the difficulty of diagnosis and the assumption that diets from developed countries supply enough thiamine to match the caloric intake (including perinatal periods), has not prompted enough research to address the role and effects of thiamine supplementation as a therapeutic strategy in the context of neurodevelopment/neurodegeneration