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doi: 10.1016/j.ebiom.2016.10.036 425 TiderencelKAHutcheonDAZieglerJ

This phospholipid bilayer (a double layer of fat molecules) acts like a protective "delivery vehicle." It shields the glutathione from stomach acid and allows it to be absorbed directly through the intestinal wall and into the bloodstream

Una vez activado, el xenobitico es conjugado a un carbohidrato, aminocido o molcula de glutatin para formar compuestos inocuos en Fase II del mecanismo de detoxificacin (Figura 2)

& Gammon, W

For instance, repeated cocaine in rodents enhanced histone H3 acetylation at the BDNF promoter in PFC, boosting BDNF transcription 175