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doi: 10.1016/j.jphotobiol.2019.111541 283 ParvathaluKChinmayeeSPreethiBSwethaAMaruthiGPritamMet al

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A patient with mutated GPX4 since embryonic development could be under chronic oxidative stress whereas the oxidative stress in an in-vitro or in-vivo assay knocking down GPX4 could be considered acute. Cells adapt to the change in gene function by upregulating other pathways