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Because Dihexa lacked pharmaceutical-grade drug-like properties for clinical development, Athira Pharma instead developed fosgonimeton (ATH-1017), a phosphate prodrug that is rapidly converted to an active HGF/c-Met-potentiating metabolite following subcutaneous administration

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The development of 3D culture models and organ-on-chip platforms brought a degree of complexity to classic in vitro for more physiological models of organs including the BBB