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This substantial reserve explains why B12 deficiency takes years to develop even when dietary intake ceases

Determination of microbiome Microbial DNA was extracted from fecal samples using stool transport and recovery (STAR) buffer (Roche, Basel, Switzerland) and SpheroLyse solution (Hain Lifescience, Nehren, Germany)

In contrast, M2 macrophages produce cytokine signals like IL-6 and IL-10 that help cancer cells evade immune surveillance, recruit endothelial cells for angiogenesis, and avoid apoptosis, thus allowing them to proliferate more freely [146, 153]

the fusion protein may possess a conformation substantially different than the native conformations of the constituent polypeptides

In small ruminants, pregnancy is a complex process that involves numerous physiological changes in pregnancy-related tissues (Kandil et al., 2025