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Conversely, MXRA8 protects gliomas from ferritin degradation-dependent ferroptosis through negatively regulating NCOA4 and upregulating FTH1, although the explicit mechanism remains uncertain[110]

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First-line systemic therapies like methotrexate (MTX), cyclosporine A (CyA), and retinoic acid are effective but can induce adverse effects such as hypertension, hepatotoxicity, and renal impairment