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The resistance across the epithelial layer (TEER) and expression and distributions of the proteins involved in tight junctions (ZO-1, occludin, and claudin-1), receptors responsible for detecting pathogens (TLR2 and TLR4), and molecules that inhibit the TLR signaling pathway increased (A20 and IRAK-M) (186)

By improving blood flow to injured or inflamed tissue, TB500 enhances oxygen and nutrient delivery, which is crucial for accelerating the healing process

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Arch Biochem Biophys 317:315323 Stoyanovsky DA, Goldman R, Jonnalagadda SS, Day BW, Claycamp HG, Kagan VE (1996) Detection and characterization of the electron paramagnetic resonance-silent glutathionyl-5, 5-dimethyl-1-pyrroline N-oxide adduct derived from redox cycling of phenoxyl radicals in model systems and HL-60 cells

The drug impairs the vesicular storage of dopamine as well (Trejo et al., 2001[77])