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Integrating multi-omics data, a pathway analysis, and computational modeling may offer powerful tools to investigate metabolic reprogramming in ECs during aging and atherosclerosis, as exemplified by Kalucka et al.s single-cell RNA-sequencing (scRNA-Seq) atlas of 11 mouse tissues, which revealed 78 EC subclusters and highlighted tissue origin as the primary determinant of EC heterogeneity, including tissue-specific metabolic profiles [234]

Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all- trans retinoic acid in acute promyelocytic leukemia

R.Clare MorrisM.ScarmeasN.ShahR

While there have been conflicting reports regarding ROS generation in cells treated with NSAIDs 53 , colon cancer cells reportedly exhibit stronger ROS generation than other cancer cell types 54,55 , which is consistent with the findings of our present study

10.1016/j.ctrv.2008.07.004 30 HanJ.YueX.ChangJ.ShiW.HuaY