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Parkinson's disease (PD) PD is the second most common neurodegenerative disease following AD, and is associated with the loss of dopaminergic neurons in the Substantia Nigra compacta (SNc)

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Incorporating psychometric and biological markers in future protocols will be essential for elucidating interindividual variability in response to ctDCS and for guiding the development of personalized neuromodulatory interventions

THP-1 cells were differentiated into macrophages by 100 nM of phorbol-12-myristate-13-acetate (Sigma-Aldrich), and differentiated into M1 by adding LPS (100 ng/mL, Sigma-Aldrich) and IFN- (20 ng/mL, R&D Systems) for 24 h, and M2 cells with M-CSF (20 ng/mL, Peprotech), IL-4 (40 ng/mL, R&D Systems), and IL-13 (40 ng/mL, R&D Systems) for 4 days