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Cytokine LEGENDPlex assay SCD mice plasma samples were 2-fold diluted, and cytokine levels were assessed with mouse LEGENDplex inflammation panel 13-plex kit (#740150, BioLegend) per manufacturers instructions

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Collectively, these findings demonstrate that small-molecule PCSK9 inhibition ameliorates AD-like pathology through coordinated enhancement of BBB-mediated A clearance and suppression of microglial inflammatory amplification, highlighting PCSK9 as a multifaceted therapeutic target and supporting a BBB-oriented strategy for AD intervention