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Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector

Tarrio, M

Lack of definitive outcomes: Many studies focus on surrogate biomarkers (GSH/GSSG, oxidative stress markers) rather than clinically meaningful endpoints

Beyond that, using a tiny Azo-tagged adapter molecule based on protein G, even an intact antibody (trastuzumab) was purified from a cell culture medium, thus efficiently separating it from the large excess of albumin