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A further study evidenced that the lncRNA CRNDE was regulated by insulin and IGFs, and suggested that CRNDE nuclear transcripts, generated from CRNDE by alternative splicing, played a role in controlling CRC cell metabolism (104)

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Normal hemoglobin levels vary by age and sex: Adult males: 13.0 g/dL or higher Adult females: 12.0 g/dL or higher Pregnant females: 11.0 g/dL or higher Children 6 to 59 months: 11.0 g/dL or higher Children 5 to 11 years: 11.5 g/dL or higher Children 12 to 14 years: 12.0 g/dL or higher Three main causes of anemia exist: Blood loss bleeding from trauma, surgery, or gastrointestinal issues Increased red blood cell destruction hemolytic anemias Decreased red blood cell production nutritional deficiencies, bone marrow problems, chronic disease The ICD-10 codes for anemia fall under category D50 through D64

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