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of 78 SNPs in nAChRs and mAChRs genes of isolated B-lymphocytes of ME/CFS, 35 were within mAChM3

Direct answer: Yes, current data suggests it remains safe with proper monitoring

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In the normal renal function group, one participant had a clinically significant vital sign abnormality (increased blood pressure) and one had a clinically significant ECG abnormality, with both reported as resolved mild TEAEs