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Age- and sex-differences in the nitric oxide synthase expression and dopamine concentration in the murine model of Parkinsons disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Response to stressful conditions ensure genes localized on SSI-1 (stress survival islet-1): acid stress, osmotic stress, bile stress in the stomach (Ryan et al., 2010) and SSI-2 (stress survival islet-2): alkaline and oxidative stress (Harter et al., 2017)

Different underlying mechanisms can produce the same clinical presentation

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Membrane-retained gH/gL monomer repRNA immunization is more immunogenic than secreted gH/gL multimers We and others have previously shown that multimerization of gH/gL through genetic fusion to self-assembling nanoparticles substantially improves its immunogenicity when delivered as recombinant protein 23,34,35